Doxycycline Can Reduce Glycocalyx Shedding by Inhibiting Matrix Metalloproteinases in Patients Undergoing Cardiopulmonary Bypass: A Randomized Controlled Trial.

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Cardiopulmonary bypass (CPB) leads to shedding of the glycocalyx of endothelial cells, resulting in a series of complications such as tissue edema and coagulatory and microcirculatory dysfunctions. Matrix metalloproteinases (MMPs) can cause glycocalyx shedding in a variety of pathological processes, but their role in the process of CPB is still unclear. We hypothesized that the MMPs inhibitor doxycycline would reduce glycocalyx shedding by inhibiting MMPs during CPB.