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Abstract: Current shock guidelines recommend norepinephrine as the first-line vasopressor to increase mean arterial pressure (MAP) and eventually restore tissue perfusion [1]. Norepinephrine (or noradrenaline) is an endogenous catecholamine, produced both in postganglionic sympathetic nerves and adrenal glands. It became part of the therapeutic arsenal for the treatment of shock during the 1950s, gaining traction ever since. Despite its ubiquitous use throughout intensive care units (ICUs) and operating rooms worldwide [2], clinical practice related to its administration is still heterogeneous. We provide here a concise and practical article on the fundamentals of vasopressor administration in critically ill patients, using norepinephrine as a paradigmatic case example.