A Pilot Randomized Controlled Study of Mild Hypercapnia During Cardiac Surgery With Cardiopulmonary Bypass

Start Date: ,

End Date: ,

A Pilot Randomized Controlled Study of Mild Hypercapnia During Cardiac Surgery With Cardiopulmonary Bypass

Objectives

To test whether targeted therapeutic mild hypercapnia (TTMH) would attenuate cerebral oxygen desaturation detected using near-infrared spectroscopy during cardiac surgery requiring cardiopulmonary bypass (CPB).

Design

Randomized controlled trials.

Setting

Operating rooms and intensive care unit of tertiary hospital.

Participants

The study comprised 30 patients undergoing cardiac surgery with CPB.

Interventions

Patients were randomly assigned to receive either standard carbon dioxide management (normocapnia) or TTMH (target arterial carbon dioxide partial pressure between 50 and 55 mmHg) throughout the intraoperative period and postoperatively until the onset of spontaneous ventilation.

Measurements and Main Results

Relevant biochemical and hemodynamic variables were measured, and cerebral tissue oxygen saturation (SctO₂) was monitored with near-infrared spectroscopy. Patients were followed-up with neuropsychological testing. Patient demographics between groups were compared using the Fisher exact and Mann-Whitney tests,

Back to All Events