H1 And H2 Antihistamines Pretreatment for Attenuation of Protamine Reactions after Cardiopulmonary Bypass: A Randomized-Controlled Study.

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Protamine administration post-cardiopulmonary bypass (CPB) can potentially cause hemodynamic instability. Histamine released from mast cells is believed to be responsible for hypotension after protamine administration. The aim of this study was to examine the effects of pretreatment with H₁ and H₂ antihistamines on changes in systemic arterial pressure following protamine administration.