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Traditionally, the functional development, testing and verification of higher level automation, control and safety functions in extracorporeal circulations systems relies very much on the conduction of animal experiments. This especially applies to functions requiring interaction with the patients physiology. Besides ethical aspects, animal experiments have the disadvantage of higher complexity, limited reproducibility and certain pathological conditions can only be represented with difficulty. An alternative to this can be Hardware-in-the-loop (HIL) simulators.In this paper we present a HIL solution to simulate the hydraulic interaction between the cannula and the connected blood vessel. We derive a hydraulic model for an elastic vessel with particular emphasis on negative transmural pressure.