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Significance: Heparin products correspond to a critical class of anticoagulant drugs. However, heparin extraction from animal tissues presents multiple challenges, ranging from insecure supply chains to contamination and significant variability. The 2008 contamination crisis and the continued growth of the heparin market emphasize the need for an alternative, reliable supply of this essential medicine. We report a robust and scalable method to synthesize animal-free bioengineered heparin with structural and functional properties similar to that of USP heparin, including the ability to be converted into a low molecular weight heparin similar to enoxaparin.