Targeting Arterial Partial Pressure of Carbon Dioxide in Acute Respiratory Distress Syndrome Patients Using Extracorporeal Carbon Dioxide Removal.

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A retrospective analysis of SUPERNOVA trial data showed that reductions in tidal volume to ultraprotective levels without significant increases in arterial partial pressure of carbon dioxide (PaCO₂) for critically ill, mechanically ventilated patients with acute respiratory distress syndrome (ARDS) depends on the rate of extracorporeal carbon dioxide removal (ECCO₂R).